https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52825 8.38 µmol/L) presented relatively elevated serum creatinine levels and a higher number of people with CKD than those in the lower quartiles. TMAO levels were significantly correlated with kidney function biomarkers, including estimated glomerular filtration rate and urinary albumin to creatinine ratio. The association between TMAO and CKD was evident (p < 0.0001) and remained significant after adjusting for risk factors of kidney disease, including age, gender, body mass index, duration of diabetes, and smoking. These findings suggest the association between plasma TMAO and CKD in patients with T2D.]]> Wed 28 Feb 2024 16:34:56 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30070 Wed 24 Nov 2021 15:53:23 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35709 Wed 17 Nov 2021 16:29:53 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30774 Wed 11 Apr 2018 11:53:38 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35660 Wed 02 Mar 2022 14:23:45 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51448 6.40 µmol/L) were associated with the risk of diabetes (OR = 3.36, 95% CI [1.26, 9.04], p = 0.02). The results presented suggest an association between plasma TMAO levels and T2D. A significant correlation was found between red meat consumption and increased levels of TMAO in T2D patients. A longitudinal study is warranted to further evaluate the correlation between TMAO and T2D.]]> Tue 05 Sep 2023 17:55:02 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52748 Thu 26 Oct 2023 09:03:10 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45006 Thu 23 Mar 2023 13:24:35 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38396 Mon 29 Jan 2024 17:47:06 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32908 Mon 23 Sep 2019 13:18:51 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39179 Mon 23 May 2022 16:16:27 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39180 n = 29/32) were included in the current analysis (male: n = 22, 36.07%). DHA-enriched fish oil supplementation increased total testosterone levels in males after adjusting for baseline levels, age and BMI. There was no treatment effect in females. Changes in testosterone levels in males were positively associated with changes to omega-3 PUFAs EPA and DHA and inversely correlated with omega-6 PUFA, arachidonic acid and dihomo-gamma-linolenic acid content in erythrocyte membranes, and was associated with beneficial changes to fasting insulin and HOMA-IR across the course of the study. DHA-enriched fish oil supplementation increases testosterone levels in overweight and obese men. Further research is warranted to substantiate these findings with a larger sample size and a longer follow-up period.]]> Mon 23 May 2022 16:16:26 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52281 Mon 09 Oct 2023 10:04:55 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36438 Mon 04 May 2020 12:30:03 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46360 Fri 18 Nov 2022 10:08:42 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40029 n= 10) were recruited with the aim of deriving a standard GlucoTRIG value for a reference meal. Volunteers consumed the reference meal (2 regular slices of wholemeal bread; 250 mL chocolate flavoured milk; 7 g butter and 11 g peanut butter) comprising of carbohydrate, fat and protein (41, 40 and 16% energy respectively) on three different occasions with a minimum washout period of 3 days. The GlucoTRIG value was determined as the difference between the product of insulin and triglyceride obtained from venous blood samples at baseline and the product of insulin and triglyceride at 180 min. Results: There were no significant differences in the participants’ dietary intakes and their metabolic parameters between three visits (P> 0.005). The GlucoTRIG value obtained from three mean values of the reference meal was found to be 19 ± 3.5. There were no significant (,i>P= 0.2303) differences observed between the GlucoTRIG values for the three visits. Conclusion: GlucoTRIG, consisting of both glycaemic and lipaemic responses, may be a physiologically relevant tool to rank foods and meals for reducing the risk of metabolic diseases. Trial registration: ACTRN12619000973112.]]> Fri 15 Jul 2022 10:11:17 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53596 Fri 08 Dec 2023 16:00:13 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53590 PD >NG, p=0.0046). Post-hoc analysis indicated significantly higher plasma NfL levels in the T2D [12.4 (5.21) pg/mL] group than in the PD [10.2 (4.13) pg/mL] and NG [8.37 (5.65) pg/mL] groups. The relationship between diabetes status and NfL remained significant after adjusting for age, sex, BMI, HOMA-IR and physical activity (adjusted r2 = 0.271, p = 0.035). Conclusions: These results show biomarker evidence of neurodegeneration in adults at risk or with T2D. Larger sample size and longitudinal analysis are required to better understand the application of NfL in people with risk and overt T2D.]]> Fri 08 Dec 2023 15:47:18 AEDT ]]>